It occurs because of connective tissue the formation of plaque within the tunica tissue under the skin of the penis. The cause is unknown. It is thought to be rheumatic or autoimmune disease. Usually this disease occurs after age 40 and may be on the back side of the penis or both sides. Regardless of where hardened penis stands bent in the opposite direction. There is pain in the late period. Sometimes it is not possible merger. It is possible to feel these masses of rigid plates during manual examination.
Although it is a harmless disease, the patient’s complaints should be treated. Rarely does it disappear on its own.
THE TREATMENT IN PEYRONIE’S DISEASE
Required treatment hasn’t found the exact solution of Peyronie’s disease yet. If the pain or twisting (torsion) in the penis is minimal, in other words, these can be tolerated by the patient and the sexuel lives of people affected by this situation, the doctor can wait before giving the treatment and there is no harm examine the patient three times a year.
When it comes to Medical treatments, one detail should not be forgotten; psychological effect of the drug which is called placebo effect is so good than the real effect of the drug.
The effect of oral medications in the treatment of Peyronie’s disease, which might be as follows:
VITAMIN E, POTABA, TAMOXIFEN, COLSISIN.
In general, all these drugs, such as whether a different effect from placebo, the patients are reluctant to serious gastrointestinal problems.
EXTRA CORPOREAL SHOCK WAVE TREATMENT
Initially influenced by the principle of breaking kidney stones, was thought to distribute the limestone plaques in the penis; but the studies show that they do not have benefits.
INTERFERON ALPHA 2 B
This substance which supports the immune system has anti-tumor effect. It can be used with Intralesional application or vessel the application. It can cause serious flu symptoms and also headache. In addition, this is a very expensive method.
USING EXTERNAL VACUUM OR OTHERWISE MECHANICAL DEVICES
Herein, purpose stretch the penis seriously and keep it into the strained atmosphere approximately 10-15 minutes. No serious effect is shown except for the supportive effect of medical therapy, applied up to 6 months 2-3 sessions a day as a very small Peyronie’s plaque.
Treatments can be locally applied to the plaque in order to distribute or dissolve the limestone plaque of the penis outside the medical treatments, were thought; nonetheless, it was found to pose Peyronie’s plaque because of being extremely painful due to trauma created by itself. A further disadvantage of these treatments which can be applied later makes the surgery difficult. Drugs most commonly used in local application: prostaglandin E1 (PGE1), verapamil, betamethasone, hyaluronidase and nicardipin.
ELECTROMOTIVE APPLICATION (EMDA)
In this method, known as iontophoresis, molecules of some drugs topically applied to the skin based on the fact that diffuses into the skin are subject to direct current. The principle is the same as injection therapy. However, this treatment has no important side effects. The only disadvantage is that an expensive application. Generally cases of the first year are more successful. (45%) used mixtures of drugs are like injection treatment. Especially young men up to 65% success reported cases not exceeding 2 cm length and limestone plate in young men.
LI PEYRONIE SWT:
Low Intensity Shockwave Therapy for PEYRONIE’S DISEASE
The Omnispec Model ED1000 is designed to deliver extracorporeal, focused, low-intensity shockwave therapy to the penile area of patients suffering of PEYRONIE’S disease.
Omnispec Model ED1000 system is a device for Extracorporeal Shockwave therapy. It non-invasively delivers low-intensity shockwaves to specific areas in the patient penile shaft and crus consequently improving local blood perfusion in this area and helps the treatment of PEYRONIE’S disease.
The procedure in ED 1000 is completely painless . The shock wave is directed to the plaque.The machine can produce120 shocks per minute.Each session lasts approximately 30-40 minutes and should be performed at least 1-2 times a week.Treatment sessions depends on the size and oldness of the plaque and varies from 6 to 24 sessions.
Surgery should be done in delayed cases. Various surgical techniques are available.
The main objective is not to shorten the size of the penis and make a penis preserving erectile function properly as a cosmetic look.